| PUBLICATIONS
 2024
Hirai K, Saito H, Kato M, Kiyama M, Hanzawa H, Nakane A, Sekiya S, Yoshida K, Kishino A, Ikeda A, Kimura T, Takahashi J, Takeda S. Evaluation of induced pluripotent stem cell differentiation into neural progenitor cell using Raman spectra derived from extracellular vesicles in culture supernatants. J Biosci Bioeng. (2024) https://doi.org/10.1016/j.jbiosc.2024.09.004
Ikeda M, Doi D, Ebise H, Ozaki Y, Fujii M, Kikuchi T, Yoshida K, Takahashi J. Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analyses. Stem Cell Rep. 19(11): 1635-1646 (2024) https://doi.org/10.1016/j.stemcr.2024.09.005
Yamagami K, Samata B, Doi D, Tsuchimochi R, Kikuchi T, Amimoto N, Ikeda M, Yoshimoto K, Takahashi J. Progranulin enhances the engraftment of transplanted human iPS cell-derived cerebral neurons. Stem Cells Transl Med. 13: 1113-1128 (2024) https://doi.org/10.1093/stcltm/szae066
Generali M, Fujita Y, Kehl D, Hirosawa M, Emmert MY, Takahashi J, Hoerstrup SP, Saito H. Purification technologies for induced pluripotent stem cell therapies. Nat Rev Bioeng (2024) doi.org/10.1038/s44222-024-00220-2
Maheshwari S, Akram H, Bulstrode H, Kalia SK, Morizane A, Takahashi J, Natalwala A. Dopaminergic cell replacement for Parkinson's disease: Addressing the intracranial delivery hurdle. J Parkinsons Dis. 14(3):415-435 (2024) doi: 10.3233/JPD-230328
Sasaki R, Ohta Y, Onoe H, Yamaguchi R, Miyamoto T, Tokuda T, Tamaki Y, Isa K, Takahashi J, Kobayashi K, Ohta J, Isa T. Balancing risk-return decisions by manipulating the mesofrontal circuits in primates. Science. 383(6678):55-61 (2024) doi: 10.1126/science.adj6645.
2023
Takakuwa N, Isa K, Yamaguchi R, Onoe H, Takahashi J, Yoshida M, Isa T. Protocol for making an animal model of "blindsight" in macaque monkeys. STAR Protoc. 4(1):101960 (2023) doi: 10.1016/j.xpro.2022.101960.
Takahashi J. Next steps in regenerative medicine. Cell Stem Cell. 30(5):509-511 (2023) doi: 10.1016/j.stem.2023.04.015.
Tsuchimochi R, Yamagami K, Kubo N, Amimoto N, Raudzus F, Samata B, Kikuchi T, Doi D, Yoshimoto K, Mihara A, Takahashi J. Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain. Stem Cell Rep. 18(4):899-914 (2023) doi: 10.1016/j.stemcr.2023.02.012
2022
Adachi H, Morizane A, Torikoshi S, Raudzus F, Taniguchi Y, Miyamoto S, Sekiguchi K, Takahashi J. Pretreatment with perlecan-conjugated laminin-E8 fragment enhances maturation of grafted dopaminergic progenitors in Parkinson's disease model. Stem Cells Transl Med. 11(7): 767-777 (2022) doi: 10.1093/stcltm/szac033
Hiramatsu S, Morizane A, Kikuchi T, Doi D, Yoshida K, Takahashi J.
Cryopreservation of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurospheres for Clinical Application. J Parkinsons Dis. 12:871-884 (2022) doi:10.3233/JPD-212934
Grinand L, Takahashi J. Automated measurement of fluorescence signals reveals a significant increase of the graft-derived neurite extension in neonates compared to aged rats. Regen Ther. 19: 97-106 (2022) doi: 10.1016/j.reth.2022.01.002
2021
Saito H, Kato M, Hirai K, Kiyama M, Ohyama K, Hanzawa H, Nakane A, Sekiya S, Yoshida K, Kishino A, Tsuchida A, Kimura T, Takahashi J, Takeda S. Analysis of extracellular vesicles as a potential index for monitoring differentiation of neural lineage cells from induced pluripotent stem cells. J Biosci Bioeng. 132(4):381-389 (2021) doi: 10.1016/j.jbiosc.2021.06.004.
Morizane A and Takahashi J. Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson's Disease. J Parkinsons Dis. 11(s2):S167-S172 (2021) doi: 10.3233/JPD-212608.
Hyun I, Clayton EW, Cong Y, Fujita M, Goldman SA, Hill LR, Monserrat N, Nakauchi H, Pedersen RA, Rooke HM, Takahashi J, Knoblich JA. ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts. Stem Cell Rep. 16(6):1409-1415 (2021). doi: 10.1016/j.stemcr.2021.05.005.
Takakuwa N, Isa K, Onoe H, Takahashi J, Isa T. Contribution of the pulvinar and lateral geniculate nucleus to the control of visually guided saccades in blindsight monkeys. J Neurosci. 41(8):1755-1768 doi: 10.1523/JNEUROSCI.2293-20.2020 (2021)
2020
Nakano-Kobayashi A, Fukumoto A, Morizane A, Nguyen DT, Le TM, Hashida K, Hosoya T, Takahashi R, Takahashi J, Hori O, Hagiwara M. Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation. Sci Adv. 6(46): eabc1428 doi: 10.1126/sciadv.abc1428 (2020)
Yuan X, Schroeter M, Obien MEJ, Fiscella M, Gong W, Kikuchi T, Odawara A, Noji S, Suzuki I, Takahashi J, Hierlemann A, Frey U. Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level. Nat Commun 11: 4854 doi: 10.1038/s41467-020-18620-4 (2020)
Takahashi J. iPS cell-based therapy for Parkinson’s disease: A Kyoto trial. Regen Ther. 13: 18-22 doi: 10.1016/j.reth.2020.06.002 (2020)
Kitahara T, Sakaguchi H, Morizane A, Kikuchi T, Miyamoto S, Takahashi J. Axonal extensions along corticospinal tracts from transplanted human cerebral organoids. Stem Cell Rep. 15(2): 467-481 doi: 10.1016/j.stemcr.2020.06.016 (2020)
Doi D, Magotani H, Kikuchi T, Ikeda M, Hiramatsu S, Yoshida K, Amano N, Nomura M, Umekage M, Morizane A, Takahashi J. Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease. Nat Commun 11: 3369 doi: 10.1038/s41467-020-17165-w (2020)
Sakai Y, Nakamura T, Okamoto I, Gyobu-Motani S, Ohta H, Yabuta Y, Tsukiyama T, Iwatani C, Tsuchiya H, Ema M, Morizane A, Takahashi J, Yamamoto T, Saitou M. Induction of the germ cell fate from pluripotent stem cells in cynomolgus monkeys. Biol Reprod. 102(3):620-638 doi: 10.1093/biolre/ioz205 (2020)
Miyawaki Y, Samata B, Kikuchi T, Nishimura K, Takahashi J. Zonisamide promotes survival of human-induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats. J Neurosci Res. 98(8): 1575-1587 doi:10.1002/jnr.244668 (2020)
Samata B, Takaichi R, Ishii Y, Fukushima K, Nakagawa H, Ono Y, Takahashi J. L1CAM is a marker for enriching corticospinal motor neurons in the developing brain. Front Cell Neurosci. doi:10.3389/fncel.2020.00031 (2020)
Torikoshi S, Morizane A, Shimogawa T, Samata B, Miyamoto S, Takahashi J. Exercise promotes neurite extensions from grafted dopaminergic neurons in the direction of the dorsolateral striatum in Parkinson’s disease model rats. J Parkinson Dis. 10(2):511-521 doi: 10.3233/JPD-191755 (2020)
Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H. Hypothalamic contribution to pituitary functions is recapitulated in vitro using 3D-cultured human iPS cells. Cell Rep. 30(1): 18-24 (2020)
Takahashi J. Preclinical evaluation of patient-derived cells shows promise for Parkinson’s disease. J Clin Invest. doi: 10.1172/JCI134031 (2020)
2019
Sunohara T, Morizane A, Matsuura S, Miyamoto S, Saito H, Takahashi J. MicroRNA-based separation of cortico-fugal projection neuron-like cells derived from embryonic stem cells. Front Neurosci. doi:10.3389/fnins.2019.01141 (2019)
Sawai T, Sakaguchi H, Thomas E, Takahashi J, Fujita M. The ethics of cerebral organoid research: Being conscious of consciousness. Stem Cell Rep. 13(3): 440-447 (2019)
Sakaguchi H, Ozaki Y, Ashida T, Matsubara T, Oishi N, Kihara S, Takahashi J. Self-organized synchronous calcium transients in a cultured human neural network derived from cerebral organoids. Stem Cell Rep. 13(3): 458-473 (2019)
Shimogawa T, Sakaguchi H, Kikuchi T, Tsuchimochi R, Sano N, Torikoshi S, Ito A, Aoyama T, Iihara K, Takahashi J. Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury. NPJ Regen Med. 4: 13 (2019)
Hermanto Y, Maki T, Takagi Y, Miyamoto S, Takahashi J. Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells. J Neurosci Res. 97(7): 828-845 (2019)
Ichisima J, Suzuki N, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito M. Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model. J Hum Genet. 64(5): 445-458 (2019)
2018
Ogura T, Sakaguchi H, Miyamoto S, Takahashi J. Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells. Development 145: dev162214 doi:10.1242/dev.162214 (2018)
Takahashi J. Stem cells and regenerative medicine for neural repair. Curr Opin Biotechnol.52: 102-108 (2018)
Hermanto Y, Sunohara T, Faried A, Takagi Y, Takahashi J, Maki T, Miyamoto S. Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia. J Neurosci Res. 96(5): 863-874 (2018)
2017
Barker RA, Parmar M, Studer L, Takahashi J. Human trials of stem cell-derived dopamine neurons for Parkinson's disease: dawn of a new era. Cell Stem Cell. 21(5): 569-573 (2017)
Morizane A, Kikuchi T, Hayashi T, Mizuma H, Takara S, Doi H, Mawatari A, Glasser M F, Shiina T, Ishigaki H, Itoh Y, Okita K, Yamasaki E, Doi D, Onoe H, Ogasawara K, Yamanaka S, Takahashi J. MHC matching improves engraftment of iPSC-derived neurons in non-human primates. Nat Commun. 8:385 (2017)
Kikuchi T, Morizane A, Doi D, Magotani H, Onoe H, Hayashi T, Mizuma H, Takara S, Takahashi R, Inoue H, Morita S, Yamamoto M, Okita K, Nakagawa M, Parmar M, Takahashi J. Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature 548: 592-96 (2017)
Kikuchi T, Morizane A, Doi D, Okita K, Nakagawa M, Yamakado H, Inoue H, Takahashi R, Takahashi J. Idiopathic Parkinson’s disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains. J Neurosci Res. 95(9): 1829-1837 (2017)
Takahashi J. Strategies for bringing stem cell-derived dopamine neurons to the clinic: The Kyoto trial. Prog Brain Res. 230: 213-226 (2017)
Sano N, Shimogawa T, Sakaguchi H, Ioroi Y, Miyawaki Y, Morizane A, Miyamoto S, Takahashi J. Enhanced axonal extension of subcortical projection neurons isolated from murine embryonic cortex using neuropilin-1. Front Cell Neurosci. doi: 10.3389/fncel.2017.00123 (2017)
Ishikawa T, Imamura K, Kondo T, Koshiba Y, Hara S, Ichinose H, Furujo M, Kinoshita M, Oeda T, Takahashi J, Takahashi R, Inoue H. Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders. Hum Mol Genet. 25(23): 5188-5197 (2017)
2016
Samata B, Doi D, Nishimura K, Kikuchi T, Watanabe A, Sakamoto Y, Kakuta J, Ono Y, Takahashi J. Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1. Nat Commun. 7:13097 (2016)
Parr CJ, Katayama S, Miki K, Kuang Y, Yoshida Y, Morizane A, Takahashi J, Yamanaka S, Saito H. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells. Sci Rep. 6:32532 (2016)
Takahashi J. Development of iPSC technology in Parkinson’s disease. Cell Gene Therapy Insights 2(3): 377-385 (2016)
Nishimura K and Takahashi J. Drug discovery toward successful cell transplantation therapy for Parkinson's disease using human pluripotent stem cells. Adv Regen Biol. 3: 31772 (2016)
Mishima T, Ishikawa T, Imamura K, Kondo T, Koshiba Y, Takahashi R, Takahashi J, Watanabe A, Fujii N, Tsuboi Y, Inoue H. Cytoplasmic Aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome. Park Relat Disord. 30: 67-72 (2016)
Katsukawa M, Nakajima Y, Fukumoto A, Doi D, Takahashi J. Fail-safe therapy by gamma-ray irradiation against tumor formation by human induced pluripotent stem cell-derived neural progenitors. Stem Cells Dev. 25(11): 815-825 (2016)
Nishimura K, Doi D, Samata B, Murayama S, Tahara T, Onoe H, Takahashi J. Estradiol facilitates functional integration of induced pluripotent stem cell-derived dopaminergic neurons into striatal neuronal circuits via activation of integrin α5β1. Stem Cell Reports. 6(4): 511–524 (2016)
Motono M, Ioroi Y, Ogura T, Takahashi J. WNT-C59, a small molecule WNT inhibitor, efficiently induces anterior cortex that includes cortical motor neurons from human pluripotent stem cells. Stem Cells Transl Med. 5(4):552-560 (2016)
2015
Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, and Sasai Y. Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat Commun. 6:8896 (2015)
Nishimura K, Murayama S, Takahashi J. Identification of Neurexophilin 3 as a novel supportive factor for survival of induced pluripotent stem cell-derived dopaminergic progenitors. Stem Cells Transl Med. 4(8): 932-944 (2015)
Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito MK. Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs. Stem Cell Reports. 4(4):561-568 (2015)
Fujita M, Hatta T, Sawai T, Takahashi J. Risk of tumorigenesis and patient hope. AJOB Neurosci. 6(1): 69-70 (2015)
Samata B, Kikuchi T, Miyawaki Y, Morizane A, Mashimo T, Nakagawa M, Okita K, Takahashi J. X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation. J Neurosci Methods. 243: 68-77 (2015)
2014
Doi D, Samata B, Katsukawa M, Kikuchi T, Morizane A, Ono Y, Sekiguchi K, Nakagawa M, Parmar M, Takahashi J. Isolation of Human Induced Pluripotent Stem Cell-derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation. Stem Cell Reports. 2(3): 337-350 (2014)
Nakagawa M, Taniguchi Y, Senda S, Takizawa N, Ichisaka T, Asano K, Morizane A, Doi D, Takahashi J, Nishizawa M, Yoshida Y, Toyoda T, Osafune K, Sekiguchi K, Yamanaka S. A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells. Sci Rep 4: 3594 (2014)
2013
Koyanagi-Aoi M, Ohnuki M, Takahashi K, Okita K, Noma H, Sawamura Y, Teramoto I, Narita M, Sato Y, Ichisaka T, Amano N, Watanabe A, Morizane A, Yamada Y, Sato T, Takahashi J, Yamanaka S. Differentiation defective phenotypes revealed by large scale analyses of human pluripotent stem cells. Proc Natl Acad Sci U S A. 110(51): 20569-20574 (2013)
Morizane A, Doi D, Kikuchi T, Okita K, Hotta A, Kawasaki T, Hayashi T, Onoe H, Shiina T, Yamanaka S, Takahashi J. Direct comparison of autologous and allogeneic transplantation of iPSC-derived neural cells in the brain of a nonhuman primate. Stem Cell Reports 1(4): 283-292 (2013)
Morizane A, Doi D, Takahashi J. Neural induction with a dopaminergic phenotype from human pluripotent stem cells through a feeder-free floating aggregation culture. Methods Mol Biol. 1018:11-19 (2013)
Nishimura K, Takahashi J. Therapeutic application of stem cell technology toward the treatment of Parkinson’s disease. Biol Pharm Bull. 36(2) 171-175 (2013)
Yoshikawa T, Samata B, Ogura A, Miyamoto S, Takahashi J. Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell–derived dopaminergic neurons. Front Cell Neurosci. 7:1110.3389/fncel.2013.00011 (2013)
Ogura A, Morizane A, Nakajima Y, Miyamoto S, Takahashi J. γ-Secretase inhibitors prevent overgrowth of transplanted neural progenitors derived from human induced pluripotent stem cells. Stem Cells Dev. 22(3): 374-382 (2013)
2012
Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, Ayaki T, Ito H, Yoshikawa K, Yamawaki S, Suzuki S, Watanabe D, Hioki H, Kaneko T, Makioka K, Okamoto K, Takuma H, Tamaoka A, Hasegawa K, Nonaka T, Hasegawa M, Kawata A, Yoshida M, Nakahata T, Takahashi R, Marchetto MCN, Gage FH, Yamanaka S, Inoue H. Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med. 4: 145-104 (2012)
Gomi M, Takagi Y, Morizane A, Doi D, Nishimura M, Miyamoto S, Takahashi J. Functional recovery of the murine brain ischemia model using human induced pluripotent stem cell-derived telencephalic progenitors. Brain Res. 1459: 52-60 (2012)
Fujimoto M, Hayashi H , Takagi Y , Hayase M , Marumo T , Gomi M , Nishimura M , Kataoka H , Takahashi J ,Hashimoto N , Nozaki K , Miyamoto S. Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia. Lab Invest. 92: 522-531 (2012)
Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Mohamed R, Suemori H, Miyamoto S, Takahashi J. Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson’s disease. Stem Cells 30(5): 935-945 (2012)
Shinoyama M, Ideguchi M, Hayashi H, Doi D, Hashimoto N, Suzuki M, Takahashi J. CTLA4-Ig promotes neuronal differentiation in the grafts of embryonic stem cell-derived neural precursor cells. Neuroscience 202: 484-491 (2012)
Kitamura A, Fujita Y, Oishi N, Kalaria RN, Washida K, Maki T, Okamoto Y, Hase Y, Yamada M, Takahashi J, Ito H, Tomimoto H, Fukuyama H, Takahashi R, Ihara M. Selective white matter abnormalities in a novel rat model of vascular dementia. Neurobiol Aging. 33(5):1012.e25-35 (2012)
2011
Kikuchi T, Morizane A, Doi D, Onoe H, Hayashi T, Kawasaki T, Saiki H, Miyamoto S, Takahashi J. Survival of human induced pluripotent stem cell–derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease. J Parkinson’s Disease 1(4): 395-412 (2011)
Gomi M, Aoki T, Takagi Y, Nishimura M, Ohsugi Y, Mihara M, Nozaki K, Hashimoto N, Miyamoto S, Takahashi J. Single and local blockade of IL-6 signaling promotes neuronal differentiation of transplanted ES cell-derived neural precursor cells. J Neurosci Res 89(9): 1388-1399 (2011)
Okita K, Matsumura Y , Sato Y, Okada A, Morizane A, Okamoto S, Hong Hyenjong, Nakagawa M, Tanabe K, Tezuka K, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells. Nat Methods, 8(5): 409-412 (2011)
Morizane A, Doi D, Kikuchi T, Nishimura K, Takahashi J. Small Molecule Inhibitors of BMP and Activin/Nodal Signals Promote Highly Efficient Neural Induction from Human Pluripotent Stem Cells. J Neurosci Res, 89(2): 117-126 (2011)
2010
Morizane A, Darsalia V, Guloglu MO, Hjalt T, Carta M, Li JY, Brundin P, A simple method for large-scale generation of dopamine neurons from human embryonic stem cells, J Neurosci Res 88(16): 3467-78 (2010)
Washida K, Ihara M, Nishio K, Fujita Y, Maki T, Yamada M, Takahashi J, Wu X, Kihara T, Ito H, Tomimoto H, Takahashi R. Nonhypotensive dose of Telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-g activation in mice with chronic cerebral hypoperfusion. Stroke 41(8): 1798-1806 (2010)
Saiki H, Hayashi T, Takahashi R, Takahashi J. Objective and quantitative evaluation of motor function in a monkey model of Parkinson’s disease. J Neurosci Methods 190(2): 198-204 (2010)
Morizane A and Takahashi J. Embryonic stem cell transplantation for the treatment of Parkinson’s disease. in Perspectives of Stem Cells. H. Ulrich (Ed.) Springer, pp245-254 (2010)
Anisimov SV, Morizane A, Correia AS. Risks and mechanisms of oncological disease following stem cell transplantation. Stem Cell Rev and Rep 6(3): 411-424 (2010)
Uemura M, Refaat M. M, Shinoyama M, Hayashi H, Hashimoto N, Takahashi J. Matrigel supports survival and neuronal differentiation of grafted embryonic stem cell-derived neural precursor cells. J Neurosci Res 88(3): 542-551 (2010)
2009
Takahashi J, Takagi Y, Saiki H. Transplantation of Embryonic Stem Cell-Derived Dopaminergic Neurons in MPTP-Treated Monkeys. Methods Mol Biol 482: 199-212 (2009)
2008
Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y. Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation. Proc Natl Acad Sci USA 105(33): 11796-11801 (2008)
Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J. Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells. J Neurosci Res 86(9): 1936-1943 (2008)
Hayashi H, Morizane A, Koyanagi M, Ono Y, Sasai Y, Hashimoto N, Takahashi J. Meningeal cells induce dopaminergic neurons from embryonic stem cells. Eur J Neurosci 27: 261-268 (2008)
Koyanagi M, Takahashi J, Arakawa Y, Doi D, Fukuda H, Hayashi H, Narumiya S, Hashimoto N. Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors. J Neurosci Res 86(2): 270-280 (2008)
2007
Takahashi J. Stem cell therapy for Parkinson’s disease. Expert Rev Neurother 7: 667-675 (2007)
Ono Y, Nakatani T, Sakamoto Y, Mizuhara E, Minaki Y, Kumai M, Hamaguchi A, Nishimura M, Inoue Y, Hayashi H, Takahashi J, Imai T. Differences in neurogenic potential in floor plate cells along an antero-posterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134(17): 3213-3225 (2007)
Watanabe K, Ueno M, Kamiya D, Nishiyama A, Matsumura M, Wataya T, Takahashi J, Nishikawa S, Nishikawa S-I, Muguruma K, Sasai Y. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25: 681-686 (2007)
Takahashi J, Morizane A. Embryonic stem cell-derived neurons and astrocytes. in Neuroscapes: Book in honour of Santiago Ramón y Cajal. DeFelipe, J., Markram, H., Wagensberg, J. (Eds.) Spanish National Research Council, Madrid, Spain, 226-227&309 (2007)
2006
Takahashi J. Stem cell therapy for Parkinson’s disease. in Stem Cells in Reproduction and in the Brain. J. Morser, S-I. Nishikawa, HR. Scholer (Eds.) Springer pp229-244 (2006)
Brederlau A, Correia AS, Anisimov SV, Elmi M, Roybon L, Paul G, Morizane A, Bergquist F, Riebe I, Nannmark U, Carta M, Hanse E, Takahashi J, Sasai Y, Funa K, Brundin P, Eriksson PS, Li JY. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson’s disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 24: 1433-1440 (2006)
Hayashi J, Takagi Y, Fukuda H, Imazato T, Nishimura M, Fujimoto M, Takahashi J, Hashimoto N, Nozaki K. Primate embryonic stem cell-derived neural progenitors transplanted into ischemic brain. J Cereb Blood Flow Metab. 26: 906-914 (2006)
Morizane A, Takahashi J, Shinoyama M, Ideguchi M, Takagi Y, Fukuda H, Koyanagi M, Sasai Y, Hashimoto N. Generation of graftable progenitors of dopaminergic neurons from mouse ES cells by a combination of co-culture and neurosphere methods. J Neurosci Res. 83: 1015-1027 (2006)
Fukuda H, Takahashi J, Watanabe K, Hayashi H, Morizane A, Koyanagi M, Sasai Y, Hashimoto N. FACS-based purification of ES cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 24: 763-771 (2006)
2005
Takagi Y, Nishimura M, Morizane A, Takahashi J, Nozaki K, Hayashi J, Hashimoto N. Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain. J Neurosurg. 103: 304-310 (2005)
Takagi Y and Takahashi J. Primate embryonic stem cells as a source of dopaminergic neurons: a novel transplantation for Parkinson’s disease. Disc Med. 5:219-223 (2005)
Fukuda H and Takahashi J. Embryonic stem cells as a cell source for treating Parkinson’s disease. Expert Opin Biol Ther. 5: 1273-1280 (2005)
Kishi Y, Takahashi J, Koyanagi M, Morizane A, Okamoto Y, Horiguchi S, Tashiro K, Honjo T, Fujii S, Hashimoto N. Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells. J Neurosci Res. 79(3): 279-286 (2005)
Takagi Y, Takahashi J, Saiki H, Morizane A, Hayashi T, Kishi Y, Fukuda H, Okamoto Y, Koyanagi M, Ideguchi M, Hayashi H, Imazato T, Kawasaki H, Suemori H, Omachi S, Iida H, Itoh N, Nakatsuji N, Sasai Y, Hashimoto N. Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model. J Clin Invest. 115(1): 102-109 (2005)
2004
Horiguchi S, Takahashi J, Kishi Y, Morizane A, Okamoto Y, Koyanagi M, Tsuji M, Tashiro K, Honjo T, Fujii S, Hashimoto N. Neural precursor cells derived from human embryonic brain retain regional specificity. J Neurosci Res. 75(6):817-824 (2004)
2003
Toda H, Tsuji M, Nakano I, Kobuke K, Hayashi T, Kasahara H, Takahashi J, Mizoguchi A, Houtani T, Sugimoto T, Hashimoto N, Palmer TD, Honjo T, Tashiro K. Stem cell-derived neural stem/progenitor cell supporting factor (SDNSF) is an autocrine/paracrine survival factor for neural stem/progenitor cells. J Biol Chem. 278(32): 35491-35500 (2003)
2002
Morizane A, Takahashi J, Takagi Y, Sasai Y, Hashimoto N. Optimal conditions for in vivo induction of dopaminergic neurons from ES cells through stromal cell-derived inducing activity. J Neurosci Res 69(6):934-939 (2002)
Takahashi J, Toda H, Hashimoto N. Neural stem cells as a tool for cell transplantation. in Strategic Medical Science Against Brain Attack.H.Kikuchi(Ed.) Springer-Verlag Tokyo pp3-20 (2002)
2001
Toda H, Takahashi J, Iwakami N, Kimura T, Hoki S, Mozumi-Kitamura K, Ono S, Hashimoto N. Grafting neural stem cells improved the impaired spatial recognition in ischemic rats. Neurosci Lett 316:9-12 (2001)
Wu S, Suzuki Y, Kitada M, Kitaura M, Kataoka K, Takahashi J, Ide C, Nishimira Y. Migration, integration, and differentiation of hippocampus-derived neurosphere cells after transplantation into injured rat spinal cord. Neurosci Lett 312:173-176 (2001)
Tanigaki K, Nozaki F, Takahashi J, Tashiro K, Kurooka H, Honjo T. Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate. Neuron 29:45-55 (2001)
2000
Nishida A, Takahashi M, Tanihara H, Nakano I, Takahashi J, Mizoguchi A, Ide C, Honda Y. Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest Ophthalmol Vis Sci. 41:4268-4274 (2000)
Toda H, Takahashi J, Mizoguchi A, Koyano K, Hashimoto N. Neurons generated from adult rat hippocampal stem cells form functional glutamatergic and GABAergic synapses in vitro. Exp Neurol. 165:66-76 (2000)
- 1999
Takagi Y, Nozaki K, Takahashi J, Yodoi J, Ishikawa M, Hashimoto N. Proliferation of neuronal precursor cells in the dentate gyrus is accelerated after transient forebrain ischemia in mice. Brain Res. 831:283-287 (1999)
Takahashi J, Palmer TD, Gage FH. Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J. Neurobiol. 38:65-81 (1999)
Takahashi M, Takahashi J, Palmer TD, Gage FH. Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol. Cell. Neurosci. 12(6):340-348 (1998)
Palmer TD, Takahashi J, Gage FH. The adult rat hippocampus contains primordial neural stem cells. Mol. Cell. Neurosci. 8:389-404 (1997)
Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR. The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell 86:465-474 (1996)
Ray J, Palmer TD, Suhonen J, Takahashi J, Gage FH.Neurogenesis in the Adult Brain: Lessons Learned from the Studies of Progenitor Cells from the Embryonic and Adult Central Nervous System.in Isolation, Characterization and Utilization of CNS Stem Cells. Gage FH and Christen Y, Eds.,Foundation IPSEN, Paris, France.pp 129-149 (1996)
Kojima M, Hoshimaru M, Aoki T, Takahashi J, Otsuka T, Asahi M, Matsuura N, Kikuchi H. Expression of heat shock proteins in the developing rat retina. Neurosci. Lett. 205:215-7 (1996)
Koide T, Takahashi J, Hoshimaru M, Kojima M, Otsuka T, Asahi M, Kikuchi H. Localization of trkB and low-affinity nerve growth factor receptor mRNA in the developing rat retina. Neurosci. Lett. 185:183-6 (1995)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Developmental expression of trkB and low-affinity NGF receptor in the rat retina. Neurosci. Lett. 151:174-177 (1993)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Extension of optic nerve fibers on genetically modified cells producing brain-derived neurotrophic factor. Neurosci. Lett. 149:83-86 (1993)
Takahashi J, Hoshimaru M, Kikuchi H, Hatanaka M. Possible activity of acidic fibroblast growth factor as a progression factor rather than a transforming factor. Biochem. Biophys. Res. Commun. 189:398-405 (1992)
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